胃肠道恶性肿瘤患者血清AFP、CEA和CA19-9的表达特征探讨

Expression characteristics of serum AFP,CEA and CA19-9 in patients with gastrointestinal malignant tumors

目的:探讨血清肿瘤标志物AFP、CEA和CA19-9在胃肠道恶性肿瘤患者中的表达特征。方法:用罗氏全自动电化学发光分析仪测定126例胃肠道恶性肿瘤患者血清AFP、CEA和CA19-9的表达水平,并分析该3项指标与临床病理因素的关系。结果:血清CEA随着肿瘤浸润深度、临床分期增加以及远处转移而表达水平上升,差异有统计学意义(P<0.05);血清CA19-9随着临床分期及远处转移表达水平上升,差异有统计学意义(P<0.05)。血清AFP表达水平在不同临床病理因素间无统计学差异(P>0.05)。结论:胃肠道恶性肿瘤患者血清CEA、CA19-9的表达水平与胃肠道恶性肿瘤患者的病情密切相关。

OBJECTIVE：To explore expression characteristics of serum tumor markers AFP,CEA,CA19- 9 in patients with the gastrointestinal malignant tumors.METHODS：Expression levels of AFP,CEA,CA19-9 in serum of 126 patients with gastrointestinal cancers were analyzed by Roche automatic electrochemical luminescence,and the relationship of these markers with clinicopathological factors were studied.RESULTS：Serum CEA expression increased with the depth of tumor invasion,clinical stage,and distant metastasis,the difference was statistically significant（P0.05）.Serum CA19-9 expression levels increased significantly with clinical stage,and distant metastasis difference（P0.05）.Serum level of AFP expression was not significantly different between the various clinical pathological factors.CONCLUSION：Expression levels of serum CEA,CA19-9 were closely related to the clinical condition of patients with gastrointestinal cancers.