骨髓间充质干细胞旁分泌作用在组织损伤修复中的研究进展

Research Progresses of Paracrine Effect of Bone Marrow Derived Mesenchymal Stem Cells on Wound Healing

骨髓间充质干细胞(BMSCs)是参与机体组织损伤修复的主要细胞类型。过去几十年,人们倾向于认为BMSCs的分化替代功能是其参与和促进组织损伤修复的主要方式。近年来,随着研究的深入,学术界提出了一种新的观点:BMSCs的旁分泌功能可能在组织修复中发挥着比分化替代功能更为关键的作用。认识BMSCs旁分泌在组织损伤修复中的作用对阐明BMSCs参与组织损伤修复的作用机制具有重要意义。本文就BMSCs旁分泌功能参与组织损伤修复的最新研究进展做一综述。

Bone marrow derived mesenchymal stem cell （BMSC） is one of the crucial cell types which plays roles in wound healing of tissues. In the last decades, it was believed that BMSCs promoted wound healing by differentiating into multiple lineages and placing the wounded tissues. In recent years, a new viewpoint arose from evidences that the paracrine effect of BMSCs might play a more important role in the process of wound healing than differentiation. Understanding the role of BMSCs paracrine in wound healing would be vital to clarify the mechanism how BMSCs take part into the proeess of wound healing. In this paper, we review the new research processes of BMSCs paracrine in wound healing of tissues.