固体脂质纳米粒制备及应用研究进展

Preparation and application of solid lipid nano-particles

目的综述固体脂质纳米粒制备及应用进展。方法以国内外有代表性的文献和资料为依据,将固体脂质纳米粒的制备及应用等情况进行了分析与归纳。结果固体脂质纳米粒的多种制备方法各有优、缺点,其中以高压乳匀法和微乳法被推崇。调整制备参数可调整药物的包封率和释药曲线。结论固体脂质纳米粒是一种性能优异、有发展前景的新型给药系统。

Objective To review the latest research progress of the solid lipid nano-particle.Methods Domestic and foreign representative literature information of solid lipid nano-particles and its application were analyzed and summarized.Results Many kinds of preparation methods of solid lipid nano-particle had advantages and disadvantages,the high pressure homogenization technique and micro-emulsion method were recommended.Adjusting preparation parameters could be adjusted drug encapsulation efficiency and drug delivering curve.Conclusion Solid lipid nano-particle was a kind of excellent performance,which could be promising new drug delivery system.