腹泻患儿粪A群轮状病毒检测结果分析

Analysis of Group A Rotavirus Infection in Children's Diarrhea

目的了解本地区近3年来腹泻儿童轮状病毒感染的发生率以及感染发生的流行趋势。方法采集患儿新鲜粪便,用A群轮状病毒胶体金法诊断试剂盒,对2009年1月-2011年12月间就诊的1226例腹泻患儿粪便行A群轮状病毒抗原检测,对检测结果进行回顾性统计分析。结果 2009年、2010年、2011年A群轮状病毒抗原检测阳性率分别为25.9%、24.9%、32.7%,2010年与2009年检出阳性率基本一致,差异无统计学意义,2011年发病率明显高于前两年(χ2=7.898,P=0.019)。感染率变化呈现明显的季节性改变,夏季低、冬春季高(χ2=54.761,P=0.000)。患病儿童年龄以6个月～2岁为主(χ2=20.119,P=0.000)。结论 A群轮状病毒感染是引起本地区儿童腹泻的重要病因,感染全年均可发生,发病率季节性变化明显,冬春季是主要流行季节,发病率有上升趋势,需要加强预防、早诊断、早治疗。

Objective To understand the incidence and the trends of rotavirus infection in children with diarrhea in this region during the past three years. Methods From 2009 to 2011 ,a total of 1226 cases of diarrhea feces were detected by group A rota- virus colloid gold assay reagents, retrospective and statistical analysis of the data from all cases were performed. Results In 2009,2010, and 2011, group A rotavirus positive rates were 25.9% ,24.9% ,32.7% respectively,in 2011 the incidence was sig- nificantly higher than that of the previous two years, X2 = 7. 898, P = 0. 019. The infection rate in different seasons were basically the same,low in summer, winter and spring high, X2 = 54. 761, P = 0. 000. Children of the age less than 2 were more common, X2 = 20.119 ,P = 0. 000. Conclusion Group A rotavirus infection was an important cause of diarrhea in children in the region. The infection could occur throughout the year, seasonal changes in the incidence was obvious, the main epidemic seasons were winter and spring. The incidence was of an upward trend. To strengthen prevention, early diagnosis, and early treatment were nee- ded.