蒙药玉簪清咽十五味丸抗炎镇痛作用的实验研究

Experimental Study on Anti-inflammatory and Analgesic Effects of Mongolian Medicine Yuzanqingyan-15 Pills

目的:探索蒙药玉簪清咽十五味丸的抗炎镇痛作用,为进一步推广临床应用提供依据.方法:采用热板法、醋酸扭体法观察玉簪清咽十五味丸的镇痛作用;采用小鼠耳肿胀法、角叉菜胶致大鼠足肿胀法观察玉簪清咽十五味丸的抗炎作用.结果:不同剂量的玉簪清咽十五味丸能明显提高小鼠热板痛阈值;对二甲苯致小鼠耳肿胀和角叉菜胶所致大鼠足趾肿胀均有明显的抑制作用.结论:玉簪清咽十五味丸具有显著的镇痛抗炎药理作用.

Objective： To study the anti-inflammatory and analgesic effects of Mongolian medicine Yuzanqingyan-15 pills,to provide a basis for further promotion its clinical applications.Methods： The analgesic effect of Yuzanqingyan-15 pills was observed by hot plate test and acetic acid writhing test;the anti-inflammatory effect was observed by ear edema method in mice and carrageenan induced rat paw edema.Results： Different doses of Yuzanqingyan-15 pills can significantly increase the pain threshold in mice hot plate test;inhibit xylene induced mice ear edema and carrageenan induced rat paw edema.Conclusion： Mongolian medicine Yuzanqingyan-15 pills has significant pharmacological effects on anti-inflammatory and analgesia.