原发性高血压患者血清维生素D水平及相关性研究

Association between primary hypertension and serum vitamin D levels

目的了解原发性高血压患者血清维生素D的变化，并探讨维生素D对原发性高血压发展的影响。方法按危险因素将140例原发性高血压患者分为低危组（1级高血压且无其他危险因素，56例）、中危组（2级高血压或1级高血压伴1—2个危险因素，53例）和高危组（3级高血压或1～2级高血压伴I〉3个危险因素或任何一级高血压伴1项靶器官损害或1种临床疾患，31例），并设立对照组（体检健康者，33例），检测4组的血清钙、磷、25-羟基维生素职[25（OH）D，]、甲状旁腺激素（PrH）。结果低危、中危、高危组25（OH）D，分别为（27±6）、（27±5）、（21±5）μg／L，对照组为（32±8）μg／L，低危组与中危组之间差异无统计学意义（P〉0．05），其余各组之间差异有统计学意义（P〈0．05）。25（OH）D，与收缩压、舒张压存在负相关（r值分别为-0．412、-0．377，均P〈0．01），与PTH、钙、磷、年龄无明显相关性。结论原发性高血压患者血清维生素D水平降低，尤其是伴有高危因素的患者血清维生素D水平降低更明显。

Objective To investigate the changes of serum vitamin D levels in primary hypertension pa- tients. Methods According to risk factors, 56 patients were selected as low risk group; 53 patients were selected as intermediate risk group; 31 patients were selected as high risk group and 33 healthy subjects were selected as nor- real control group. The 25-hydroxyvitamin D3 was measured with enzyme-linked immunoassay（ELISA）. The statisti- cal data was analyzed by SPSS 18. 0 software. Results The sex and age of four groups objects were not significantly different. The 25 （OH）D3 of low risk group was （27 ± 6 ） μg/L; the 25 （OH） D3 of intermediate risk group was （ 27 ± 5 ） μg/L. The 25 （OH） D3 of high risk group was （ 21± 5 ） μg/L. The 25 （OH） D3 of the healthy subjects was （32 ＋ 8）Ixg/L. The 25（OH） D3 of low risk and high risk and the healthy groups objects were significantly different （P 〈 0. 05）. With simple regression analysis, the 25 （OH） D3 was positively associated with systolic pressure and diastolic pressure （r = -0. 412, -0. 377, all P 〈 0. 01 ） , but not significantly associated with the parathyroid hor- mone, calcium, phosphorous and age. Conclusion There is a high level of hypovitaminosis D in primary hyperten- sion patients.