经皮椎体成形术治疗骨质疏松性椎体骨折不愈合

Pereutaneous vertebroplasty in treatment of nonunion of osteoporotic vertebral fractures

目的探讨经皮椎体成形术治疗骨质疏松性椎体骨折不愈合的临床效果。方法回顾性分析自2006年9月至2010年7月本院采用经皮椎体成形术治疗骨质疏松性椎体骨折不愈合患者15例的临床资料。术前、术后2d,6个月进行疼痛视觉模拟评分（VAS），评价临床治疗效果，记录骨水泥注入量及手术并发症。结果随访6—12个月，术后6个月和术后2dVAS评分明显低于术前[（2．4±0．4）分、（4．4±0．5）分比（9．3±0．6）分，差异有统计学意义，t=3．2407、4．9427，均P〈0．01]。术后6个月与术后2dVAS评分比较差异无统计学意义（P〉0．05）。骨水泥注人量为2．9～4．5ml，平均3．4ml。所有患者均无骨水泥渗漏导致的临床并发症。结论经皮椎体成形术治疗骨质疏松性椎体骨折不愈合是安全、有效的。

Objective To evaluate percutaneous vertebroplasty （PVP）in treating patients suffering from nonunion of osteoporotic vertebral body compression fracture. Methods PVP was performed in 15 cases with nonunion of osteoporotic vertebral body compression fracture during the period of September 2009-July 2010. The curative effect of PVP was evaluated by measuring visual analogue score （VAS）. The VAS at different time points were compared and statistically analyzed. The complications were recorded. Results The average follow-up period was 9 months. The patients were followed up for 6 to 12 months, VAS score of six months and two days was significantly lower than that of the preoperative [ （2. 4 ±0. 4）, （9. 3 ±0. 6） scores vs （4. 4 ±0. 5） scores], the difference was statistically significant （t = 3. 2407 and 4. 9427, all P 〈 0. 01 ）. There was a statistically significant diference （ P 〈 0. 05 ） between pre-PVP and post-PVP. No complications due to bone cement leakage occured in all patients. The average volume of cement injected into each vertebral body was 3. 4 ml （range 2. 9-4. 5 ml）. Conclusion For patients with nonunion of osteoporotic vertebral body compression fracture,PVP is a safe and effective treatment.