地佐辛预防全身麻醉苏醒期患者躁动的临床观察

Clinical effects of dezocine in preventing emergence agitation during general anesthesia

目的观察地佐辛预防全身麻醉苏醒期躁动的效果。方法选择美国麻醉师协会Ⅰ-Ⅱ级择期手术患者80例，完全随机分为观察组和对照组，每组40例。观察组患者于手术结束前30min给予静脉注射地佐辛注射液0．1mg／kg，对照组患者则接受常规药物维持麻醉。结果观察组全身麻醉苏醒期Ramsay镇静评分1分的发生率在5、10、20、30min分别为2．5％（1例）、5．0％（2例）、5．0％（2例）、7．5％（3例），明显低于对照组的12．5％（5例）、20．0％（8例）、30．0％（12例）、32．5％（13例），2．3、4分相同时间点组间差异均有统计学意义（均P〈0．05）；2组患者的呼吸恢复、睁眼、拔管时间的比较差异均无统计学意义（P〉0．05）。结论地佐辛可有效预防全身麻醉苏醒期兴奋躁动的发生，采用0．1mg／kg剂量时苏醒质量好，无明显不良反应。

Objective To observe the effect of dezocine preventing emergence agitation during general anesthesia. Methods Eighty patients of American Society of Anesthesiologists （ASA）Ⅰ-Ⅱundergoing elective surgery were randomly divided into two groups： observation group and control group （40 cases in each group）. The observation group was given intravenous injection of dezocine 0.1 mg/kg 30 minutes before the end of operation and patients in the control group received routine drug anesthesia. Results The incidence of Ramsay score 1 point in revive stage of general anesthesia in observation group of 5,10,20,30 rain are respectively 2.5% （ 1/40）, 5.0% （2/40）, 5.0% （2/40）, 7.5% （3/40）, significantly lower than the control group, 12.5% （5/40）, 20.0% （8/ 40）, 30.0% （ 12/40 ）, 32.5 % （13/40）. The difference was statistically significant （ all P 〈 0.05 ）. Between the two groups, the breathing recovery time, eyes open time and extubation time were not statistically different （P 〉 0.05 ）. Conclusion Dezocine may be effective in preventing exciting and restlessness of patients recovery from general anesthesia with good consciousness and few adverse reactions.