临床肺部感染评分干预对VAP患者的疗效观察

Effect of pulmonary infection score intervention on ventilator-associated pneumonia patients

目的探讨临床肺部感染评分对VAP患者抗生素选择策略进行干预后对预后的影响。方法采用随机、对照、临床研究。连续入选符合诊断标准的VAP患者56例,随机分为2组:A组(评分干预组,28例)临床肺部感染评分大于6分者抗生素选择策略采用降阶梯治疗方案,小于6分者采用常规升级治疗方案。B组(常规组,28例)按常规自然决定抗生素的选择和疗程。比较两组患者抗生素使用疗程、病死率及真菌定植发生率等。结果 A组抗生素使用疗程、病死率显著低于B组,B组真菌定植发生率高于A组。结论临床肺部感染评分干预抗生素选择策略对改善VAP的疗效、预后具有良好效果。

Objective To explore the effect of pulmonary infection score on the prognosis of the ventilator-associated pneumonia（VAP）patients after the intervention of antibiotic choice strategy.Methods A randomized,controlled and clinical study was employed.56 cases of VAP patients were included and randomized into 2 groups： a score intervention group（group A,28 cases） and a routine group（group B,28 cases）.Comparative study was conducted between the two groups of patients in terms of the antibiotics course of treatment,mortality and the incidence of fungal colonization.Results The antibiotics treatment course and mortality of group A were significantly shorter or lower than those of group B,while the fungal colonization rate of group B was notably higher than that of group A.Conclusion Pulmonary infection score intervention in antibiotics choice strategy has a good clinical effect on the improvement of the treatment and prognosis of VAP.