糖尿病患者血清可溶性细胞间粘附分子-1和可溶性血管细胞粘附分子-1变化的研究

Study on changes of serum soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 in diabetic patients

目的 研究糖尿病患者血清可溶性细胞间粘附分子 - 1(s ICAM- 1)和可溶性血管细胞粘附分子 - 1(s VCAM- 1)水平的变化。方法 应用酶联免疫吸附法 (EL ISA)检测了 18例 1型糖尿病和 47例 2型糖尿病患者及 2 0例健康对照者的血清 s ICAM- 1、s VCAM- 1以及甘油三酯 (TG)水平。结果 1血清 s ICAM- 1和 s VCAM- 1水平 ,1型、2型糖尿病患者组均显著高于健康对照组 (P<0 .0 5～ 0 .0 1) ,2型糖尿病有微血管病变组又高于无微血管病变组 (P<0 .0 5～ 0 .0 1) ,1型糖尿病与 2型糖尿病组之间无显著性差异 ;2血清 s VCAM- 1水平 ,2型糖尿病的高甘油三酯血症组 (A组 )、高甘油三酯血症合并高血压组 (B组 )高于单纯高血压组 (C组 )和甘油三酯、血压正常组 (D组 ) (P均 <0 .0 5 ) ;3 1型糖尿病和 2型糖尿病患者血清 s ICAM- 1和 s VCAM- 1之间均呈正相关关系 (r=0 .83、0 .5 3,P均 <0 .0 1)。结论 12型糖尿病患者血清 s VCAM- 1升高与高甘油三酯血症有关 ;2血清 s ICAM- 1和 s VCAM- 1参与了糖尿病微血管病变的发病过程 。

Objective To investigate the changes of serum levels of soluble intercellular adhesion molecule 1(sICAM 1) and soluble vascular cell adhesion molecule 1 (sVCAM 1) in patients with diabetes mellitus (DM).Methods Serum levels of sICAM 1,sVCAM 1 were measured with ELISA in 18 cases of type 1 diabetic patients,47 cases of type 2 diabetic patients and 20 cases of healthy subjects.Results ①The serum levels of sICAM 1 and sVCAM 1 in type 1 and type 2 diabetic patients were much higher than those in healthy controls respectively ( P <0 05～0.01),serum levels of sICAM 1 and sVCAM 1 in type 2 diabetic patients with microangiopathy were much higher than those in type 2 patients without microangiopathy ( P <0 05～0.01),there was no difference in serum sICAM 1 and sVCAM 1 between type 1 diabetic patients and type 2 diabetic patients;②Serum levels of sVCAM 1 in type 2 diabetic patients with hypertriglyceridemia (group A),hypertriglyceridemia complicating hypertension (group B) was much higher than those in type 2 diabetic patients with hypertension (group C),with normal triglyceridemia and normal blood pressure (group D) respectively ( P <0 05),③Serum levels of sICAM 1 in type 1 and type 2 diabetic patients had positive correlation with serum levels of sVCAM 1 ( r =0.83, r =0.53, P <0 01).Conclusion ①The elevation of serum levels sVCAM 1 in type 2 diabetic patients is related to hypertriglyceridemia;②Serum sICAM 1 and sVCAM 1 might participate in the course of diabetic microangiopathy.Serum levels of sICAM 1 and sVCAM 1 are the useful markers in reflecting disease evolution in diabetes mellitus.