非小细胞肺癌外周血LUNX-mRNA的表达

Expression of LUNX-mRNA in Peripheral Blood of Patients with Non-small-cell Lung Cancer

目的探讨非小细胞肺癌(NSCLC)患者外周血中LUNX-mRNA表达及其临床意义。方法应用反转录聚合酶链反应(RT-PCR)技术检测34例良性肺部病变及56例NSCLC患者外周血LUNX-mRNA表达情况。结果 NSCLC患者外周血LUNX-mRNA阳性表达率为58.93%,而对照组均无表达。外周血LUNX-mRNA阳性表达率与NSCLC患者的年龄、性别、吸烟、民族等临床特征无关(P>0.05),与肿瘤部位、病理类型等病理特征无关(P>0.05),而与NSCLC的分化程度、临床分期有关(P<0.05)。结论 LUNX-mRNA可作为NSCLC患者的外周血微转移的良好分子标志物,其阳性表达与癌组织的分化程度、临床病理分期有关。

Objective To study the expression of LUNX-mRNA in peripheral blood of patients with non-small-cell lung cancer（NSCLC） and its clinical significance. Methods RT-PCR was used to detect the expression of LUNX-mRNA in peripheral blood of 90 patients including 56 cases of NSCLC and 34 cases of benign lung lesions（control group）. Results The positive expression of LUNX-mRNA was 58.93% in peripheral blood of NSCLS patients while no positive expression in the control group. The positive expression of LUNX-mRNA wasn＇t correlated with clinical characteristics of NSCLC patients such as age, gender, smoking history and nationality （P 〉 0.05 ）, and pathological characteristics such as tumor location and pathological type, but was correlated with cell differentiation and TNM staging of NSCLC （ P 〈 0.05 ）. Conclusion LUNX-mRNA can be used as a valuable molecular marker for detecting micrometastasis in peripheral blood of NSCLC patients, and its positive expression is correlated with cell differentiation and TNM staging of lung cancer tissues.