祛敏平喘方治疗慢性持续期儿童哮喘51例

Clinical observation of "Allergy-removing and Asthma-relieving Decoction" in treating chronic persistent asthma in 51 children

目的观察祛敏平喘方治疗慢性持续期儿童支气管哮喘临床疗效。方法将78例病例随机分为治疗组(51例)和对照组(27例),治疗组服用中药祛敏平喘方,对照组服用孟鲁司特钠咀嚼片;两组均治疗2个月。观察哮喘控制情况、中医症状改善情况及血IgE水平、白三烯受体1(CysL T1-Receptor)mRNA和调节激活正常T细胞表达和分泌细胞因子(RANTES)表达情况。结果①两组治疗后、治疗后2个月哮喘控制量表积分均较本组治疗前明显提高,差异有统计学意义(P<0.05);组间比较,治疗后2个月积分差异有统计学意义(P<0.05)。②治疗组治疗前后中医证候总积分分别为(11.2±1.4)分、(8.5±1.7)分;组内比较,差异有统计学意义(P<0.05)。对照组治疗前后中医证候总积分分别为(11.7±2.0)分、(10.9±1.5)分;组内比较,差异无统计学意义(P>0.05)。两组治疗后比较,总积分差异有统计学意义(P<0.05)。③治疗组IgE水平及CysL T1-Receptor mRNA表达治疗前后组内比较,差异有统计学意义(P<0.05);对照组仅IgE水平治疗前后组内比较,差异有统计学意义(P<0.05)。组间治疗后比较,IgE水平及CysL T1-Receptor mRNA、RANTES表达差异无统计学意义(P>0.05)。结论祛敏平喘方治疗慢性持续期儿童支气管哮喘疗效良好。

Objective To observe the efficacy of “Allergy-removing and Asthma-relieving Decoction”in childhood chronic persistent asthma. Methods Seventy- eight cases were randomly divided into treatment group （n = 51 ） and control group （n = 27 ）. The cases in the treatment group were given “Allergy-removing and Asthma-relieving Decoction”, and those in the control group received Singnlairl. The treatment courses were two months for both groups. Asthma controlling situa- tion, and the improvement of traditional Chinese medicine symptoms were observed ： and the levels of IgE, CysL T1 -Receptor mRNA and RANTES expression were detected. Results ①In both groups, the scores of asthma control scale after treatment and 2 months after treatment were all lower than those before treatment （ P 〈 0.05 ） ; comparison between the two groups showed a significant difference in the scores 2 months after treatment （ P 〈 0.05 ）. ②The total scores of TCM syn- drome in the treatment group before and after total points were （ 11.2 ＋ 1.4） and （ 8.5 ~ 1.7 ） respectively, with a significant difference between them （ P 〈 0.05 ）. The total scores of TCM syndrome in the control group before and after total points were （ 11.7 ：t： 2.0） and （ t0.9 ~ 1.5 ） respectively, with no significant difference between them （P 〉 0.05 ）. There was a significant difference after treatment between the groups （P 〈 0.05 ）. ③Comparison between before and after treatment, IgE level and CysL T1 -Receptor mRNA expression in treatment group, IgE level in control group showed significant difference （ P 〈 0.05 ）. After treat- ment, IgE level and CysL T1 -Receptor mRNA, the expression of RANTES in both groups had no significant difference （ P 〈 0.05 ）. Conclusion “ Allergy-remo- ving and Asthma-relieving Decoction”is effective in treating chronic persistent period of childhood bronchial asthma.