期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

GCKR基因多态性与2型糖尿病 被引量：2

The Polymorphisms of GCKR Gene and Type 2 Diabetes Mellitus
下载PDF
导出
摘要 2型糖尿病(T2DM)是多基因遗传变异和环境等多重因素共同作用的结果。葡萄糖激酶调节蛋白(GCKR)被认为是T2DM重要的易患基因之一。其两个单核苷酸多态性(rs780094和rs1260326)基因遗传位点与血糖水平、胰岛素分泌、三酰甘油水平及T2DM的发病有显著相关性。GCKR基因多态性可能通过降低胰岛素的分泌、降低血糖和增加三酰甘油水平,从而降低T2DM的易患性。 Type 2 diabetes mellitus is the result of multiple genes and multiple environment factors.Glucokinase regulatory protein（GCKR）is considered to be one of the important susceptibility genes in type 2 diabetes mellitus（T2DM）.Its two single nucleotide polymorphisms（rs780094 and rs1260326）are significantly correlated with blood glucose levels,insulin secretion,triglyceride levels and T2DM pathogenesis.GCKR polymorphism reduces the risk of T2DM possibly by reducing insulin secretion,lowering blood glucose and increasing triglyceride levels.
作者 张陆燕 刘静
机构地区 兰州大学第一临床医学院 甘肃省人民医院内分泌科
出处 《医学综述》 2012年第18期3019-3022,共4页 Medical Recapitulate
关键词 葡萄糖激酶调节蛋白 2型糖尿病 基因多态性 Glucokinase regulatory protein Type 2 diabetes mellitus Gene polymorphisms
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献20

  • 1Van Sehaftingen E. A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructoe 6- phophate and fructose 1-phosphate [ J ]. Eur ./Biochem, 1989,179 ( 1 ) :179-184.
  • 2Alvarez E, Roncero I, Chowen JA, et al. Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain[ J]. J Neurochem ,2002,80( 1 ) :45-53.
  • 3Arden C, Baltrusch S, Agius L. Glucokinase regulatory protein is associated with mitochondria in hepatocytes[J]. FEBS Lett,2006, 580 ( 8 ) :2065-2070.
  • 4Agius L, Peak M, Van Schaftingen E. The regulatory protein of glu- cokinase binds to the hepatocyte matrix, but, unlike glucokinase, does not translocate during substrate stimulation [ J ]. Biochem J, 1995,309 ( Pt 3 ) :711-713.
  • 5Beer NL, Tribble ND, McCulloch LJ, et al. The P446L variant in GCKR associated with fasting plasma glucose and triglyeefide lev- els exerts its effect through increased glucokinase activity in liver [ J]. Hum Mol Genet ,2009,18 ( 21 ) :4081-4088.
  • 6De la lglesia N, Mukhtar M, Seoane J, et al. The role of the regula- tory protein of glucokinase in the glucose sensory mechanism of the hepatocyte [ J]. J Bio Chem,2000,275 (14) : 10597-10603.
  • 7KCster B, Fenger M, Poulsen P, et al. Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population E J ]- Diabet Med, 2005,22 ( 12 ) : 1677-1682.
  • 8Rees MG, Wincovitch S, Schultz J, et al, Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk [J]. Diabetologia,2011,55( 1 ) :114-122.
  • 9Vaxillaire M, Cavalcanti-Proenca C, Dechaume A, et al. The com- mon P446L polymorphism in gCKR inversely modulates fasting glu- cose and triglyceridc levels and reduces type 2 diabetes risk in the DESIR prospective genera] french population [ J ]. Diabetes, 2009, 57( 8 ) :2253-2257.
  • 10Shen HQ, Pollin TI, Damcott CM, et al. Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study [ J]. Hum Genet, 2009, 126 (4) :567-574.

同被引文献13

引证文献2

二级引证文献10

医学综述
2012年 第18期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部