摘要
高三酰甘油(TG)腹型肥胖是脂肪组织储存了过多的三酰甘油相关的脂质。高TG血症除引起促进动脉硬化和血栓形成外,对胰岛B细胞分泌功能及糖代谢产生一定影响。有研究证明,高TG可以导致胰岛素的分泌异常、外周胰岛素抵抗(IR)、胰岛B细胞的凋亡。越来越多的研究表明,腹型肥胖与IR和糖代谢异常密切相关,脂肪组织尤其是内脏脂肪组织是IR的始发部位。高TG腹型肥胖引起糖代谢紊乱主要是引发胰岛素分泌障碍和IR。现就高TG腹型肥胖对糖代谢异常的相关研究进展进行综述。
High triacylglycerol（TG）is a state of excessive TG lipids storage in fatty tissue.Hyper TG affect endocrine function of pancreatic islets B cell and glucose metabolism besides promoting arteriosclerosis and thrombosis.Studies have indicated that hypertriglycerol can induce insulin secretory abnomality,insulin resistance,and apoptosis.Studies indicate that abdominal obesity is associated with insulin resistance and disorders of glucose metabolism.Adipose tissue especially the visceral fat tissue is the initial position of insulin resistance.The hypertriglyceridemia-abdominal obesity induce disorders of glucose metabolism,the main reason is that triggers the insulin secretion obstacles and insulin resistance.Here is to make a review on the related research and development between hypertriglyceridemia-abdominal obesity and disorders of glucose metabolism.
出处
《医学综述》
2012年第18期3027-3030,共4页
Medical Recapitulate
关键词
高三酰甘油
腹型肥胖
糖代谢
胰岛素
High triacylglycerolol
Abdominal obesity
Glucose metabolism
Insulin
