帕瑞昔布钠在下肢骨折内固定取出术中超前镇痛作用研究

Research of Sodium Parecoxib Function on Preemptive Analgesia in Patients Undergoing Removal of Internal Fixation for Lower Extremity Fractures

目的观察帕瑞昔布钠在下肢骨折内固定取出术中的超前镇痛作用。方法 40例择期下肢骨折内固定取出术患者,随机分为超前镇痛组(P)和对照组(C)。超前镇痛组在术前30 min静脉注射帕瑞昔布钠40 mg,对照组术前30 min静脉注射生理盐水2 mL,观察术后6、12、24 h VAS疼痛评分及术后止痛药的使用情况。结果超前镇痛组术后6、12、24 h患者VAS评分显著低于对照组(P<0.05),止痛药使用人次少于对照组(P<0.05)。结论下肢骨折内固定取出术前静脉注射帕瑞昔布钠,有良好的术后镇痛效果,表现出一定的超前镇痛作用。

Objective To observe the preemptive analgesia effect of sodium parecoxib during the removal operation of internal fixation for lower extremity fracture. Methods 40 patients were randomized into two groups of P（ injected iv. sodium parecoxib 40 mg at 30 rain before operation） and C（ injected iv. normal saline 2 mL as the contrel）. Postoperative pain was evaluated with VAS and number of patients who demanded analgesics at 6h, 12h,24h after surgery was recorded. Results VAS score was lower in group P than group C at 6,12 and 24h after surgery（ P 〈 0.05 ）. The number of patients who demanded analgesics was lower in group P than group C at 6,12 and 24h after surgery （ P 〈 0.05 ）. Conclusion Preoperative injection of sodium parecoxib has satisfied effect of analgesia in patients undergoing removal of internal fixation for lower extremity fracture, and a certain preemptive analgesia effect is seen.