^(99m)Tc-MIBI头颈部肿瘤阳性显像临床应用研究

Clinical application of positive scintigraphy in head and neck tumors with ^(99m)Tc-MIBI

目的 :探讨99mTc -甲氧基异丁基异腈(MIBI)阳性显像诊断头颈部肿瘤的临床价值。材料和方法 :对53例经病理证实的头颈部恶性肿瘤、良性肿瘤和炎症进行99m Tc -MIBI平面和/或断层显像。结果 :37例恶性肿瘤 ,35例显像为阳性 ;16例良性病变 ,13例显像为阴性 ,敏感性为94 6 % ,特异性为81 3 % ,准确性为90 6 %。37例恶性肿瘤中 ,16例喉癌病人病理证实无淋巴结转移 ,显像中淋巴结均为阴性 ;12例有淋巴结转移者 ,7例淋巴结显像为阳性 ,敏感性为58 3 % ,特异性为100 % ,准确性为82 1 %。结论 :99mTc-MIBI头颈部肿瘤阳性显像简便无创 ,在头颈部病变的定性诊断中具有一定的临床价值。可为临床的病变分期、手术术式的选择。

Objective:To investigate the clinical value of 99mTc-MIBI scintigraphy in diagnosing head and neck tumors.Materials and Methods:Fifty-three patients with malignant and benign lesions comfirmed by pathology underwent 99mTc-MIBI plane and/or tomographic positive scintigraphy.Results:35 lesions were seen in 37 malignant lesions with 99m Tc-MIBI scintigraphy.13 in 16 benign lesions had no concentration of 99m Tc-MIBI.The sensitivity,specificity and accuracy were 94.6%,81.3% and 90.6%,respectively.There was no concentration of 99m Tc-MIBI in lymph nodes which had no metastatic involvement comfirmed by pathology in 16 patients with laryngocarcinoma.Seven in twelve lymph nodes which had metastatic involvement comfirmed by pathology were seen in 99m Tc-MIBI scintigraphy.The sensitivity,specificity and accuracy were 58.3%,100% and 82.1%,respectively.Conclusion:The positive scintigraphy in head and neck tumors with 99m Tc-MIBI was simple and non invasive.It has clinical value in qualitively diagnosing head and neck lesions.It can supply valuable information in grading lesions,selecting operation pattern,and working out treatment program.