灯盏花素对肾上腺素所致心律失常的保护作用

The Effects of Breviscapine on Experimental Arrhythmias induced by Adrenaline

目的 :观察并比较灯盏花素、普萘洛尔对心律失常的保护作用。方法 :以静脉缓慢恒速注射肾上腺素诱发大鼠发生多种心律失常。结果 :灯盏花素 (8mg/kg)和普萘洛尔 (1mg/kg)均可使肾上腺素诱发的大鼠心律失常发生时间延迟、严重程度减轻、死亡率降低 (与生理盐水组比较 ,P <0 .0 5 ) ,灯盏花素与普萘洛尔的效果相近。结论 :灯盏花素可有效地预防肾上腺素过量所导致的心律失常。

Object:Investigating the effects of breviscapine on adrenaline-induced arrhythmias and comparing with proprenolol.Method:Through constant iv of adrenaline,varide arrhythmias was induced in rats.Results:Breviscapine(8?mg/kg) and proprenolol(1?mg/kg) may delay the onset time of arrhythmias,decrease the rate of death.Conclusion:breviscapine are effective on arrhythmias induced by adrenaline in rats.