黄精多糖对哮喘患者血清总IgE、IL-4、INF-γ及肺功能的影响

Effect of Yellow refined polysaccharides on serum total IgE,IL-4,INF-γ and lung function in patients with asthma

目的探讨黄精多糖对哮喘患者血清总IgE、IL-4、INF-γ及肺功能的影响。方法选择哮喘急性发作期患者60例,随机分为治疗组和对照组,每组各30例,所有患者均给予相对应级别剂量的糖皮质激素等常规治疗,黄精多糖治疗组于常规治疗基础上加用黄精多糖注射液,每月连续用7天,疗程3个月。所有患者在治疗前及治疗3个月后检测血清总IgE、IL-4、INF-γ浓度,并测定肺功能(FEV1%和PEF%)。结果与治疗前比较,治疗组患者血清总IgE、IL-4含量较治疗前明显降低(P<0.01);血清INF-γ水平显著升高(P<0.01),肺功能明显改善(P<0.01)。与对照组比较,治疗组患者血清总IgE和IL-4含量明显降低(P<0.05);血清INF-γ水平显著升高(P<0.01),肺功能明显改善(P<0.05)。结论黄精多糖能有效改善急性发作期哮喘患者肺功能,并能降低血清总IgE和IL-4水平,从而降低哮喘患者的气道高反应性。

Objective To investigate the effect of Yellow refined polysaccharides on serum total IgE, IL-4, INF-γ and lung func- tion in patients with asthma. Methods 60 cases of patients with acute exacerbation of asthma, were randomly divided into treatment group and control group, 30 cases in each group, all the patients were given the corresponding level doses of glucocorticoids and other con- ventional treatment, and yellow refined polysaccharides in the treatment group on the basis of conventional therapy, monthly for 7 days, the course was 3 months. All patients before treatment and after treatment for 3 months, detection of total serum IgE, IL-4, INF-γ concen- tration, and the determination of lung function （ FEV1% and PEF% ） were made. Results Compared with before treatment, the treat- ment group patients serum total IgE, IL-4 content significantly decreased （ P 〈 0. 01 ） ; serum INF-γ level increased significantly （ P 〈 0. 01 ） , lung function improved significantly （ P 〈 0.01 ）. Compared with the control group, the total serum IgE and IL-4 levels of treat- ment group patients were significantly reduced （ P 〈0. 05 ） ; serum INF-γ level increased significantly （ P 〈 0. 01 ） , lung function im- proved significantly （P 〈 0. 05 ）. Conclusion The Yellow refined polysaccharides can improve lung function in patients with acute exacerbation of asthma, and can reduce the total serum IgE and IL-4 levels, thereby reducing the airway hyperresponsiveness in patients with asthma.