莫西沙星与左氧氟沙星治疗耐药性肺结核的疗效比较

The curative effect comparison of moxifloxacin and levofloxacin in the treatment of drug-resistant pulmonary tuberculosis

目的观察和比较莫西沙星与左氧氟沙星治疗耐药性肺结核的临床疗效。方法 78例耐药性肺结核患者随机分为两组,莫西沙星组在基础抗结核药物治疗上加用莫西沙星,左氧氟沙星组则在基础抗结核药物治疗上加用左氧氟沙星。观察和比较两组临床疗效及不同时期痰菌转阴情况。结果莫西沙星组治疗总有效率(94.9%)明显高于左氧氟沙星组(76.9%)(P<0.05);结论莫西沙星治疗耐药肺结核疗效显著,可提高痰菌转阴率。

Objective To observe and compare the clinical curative effect of moxifloxacin and levofloxacin in the treatment of drug-resistant pulmonary tuberculosis. Methods 78 patients with drug-resistant pulmonary tuberculosis were randomly divided into two groups. The moxifloxacin group was treated with moxifloxacin on the basis of anti-tuberculosis drug therapy, and the levofloxacin group was treated with levofloxacin on the basis of anti-tuberculosis drug therapy. The clinical curative effect and sputum negative conversion in dif- ferent periods of the two groups were observed and compared. Results The total effective rate of moxifloxacin group （94. 9% ） was signif- icantly higher than that of levofloxacin group （76.9%） （ P 〈 0. 05 ）. The rate of mycobacterium tuberculosis seroconversion at different periods in moxifloxacin group were higher than that of levofloxacin group （ P 〈 0. 05 ）. Conclusion The treatment of moxifloxacin drug- resistant pulmonary tuberculosis had a good curative effect. It could improve the rate of sputum negative conversion, and should be worthy of clinical application.