新斯的明对动物镁中毒的拮抗作用

The Counteractive Effect of Neostigmine Against Poisoning of Animals Caused by Magnesium Ion

目的 观察新斯的明对动物镁中毒的拮抗作用。方法 通过动物实验观察新斯的明和钙剂对离体蛙心及家兔镁中毒后心肌收缩力、血压及呼吸的影响 ,并加以比较。结果 新斯的明对镁离子引起的心肌收缩力减弱有对抗作用 ,钙剂则不能对抗之 ;对家兔镁中毒后的血压及呼吸抑制 ,新斯的明均可对抗 ,在用药后 15 s,40 s及 3min血压分别升高6 .6 7± 0 .6 7,4.40± 0 .40 ,7.33± 0 .6 7k Pa,钙剂组依次为 3.0 0± 0 .6 7,2 .33± 0 .6 9,2 .6 0± 0 .38k Pa,经统计学处理 ,P值均<0 .0 1,结果有显著性差异 ,在呼吸改善方面 ,仅在用药后 15 s时钙剂组明显强于新斯的明组 (P<0 .0 1) ,40 s及 3min时均无统计学差异 (P值 >0 .0 5 )。结论 新斯的明能有效地解救镁中毒 ,其疗效优于钙剂。

Objective Observe the counteractive effect of neostigmine against poisoning of animals caused by magnesium ion.Method Through animal experiments,observe the effects of neostigmine and calcium ion on the contractive force of cardiac muscles of frog heart seperated from the moin body and the blood pressure and respiration of domestic rubbits after the frog heart and domestic rabbits are poisoned by magnesium ion.The compare the results.Result Neostigmine can counteract the decrease in contractive force of the frog heart caused by poisoning of magnesium ion,while calcium ion can't.Nestigmine can counteract not only the rabbits' decrease of blood pressure but also their estraint of respiration caused by poisoning of magnesium ion.At 15,40 and 180 seconds after neostigmine is given,the blood pressure rises 6.67±0.67,4.40±0.40,7.33±0.67kPa respectively;while after calcium ion is given,the blood pessure rises as follows: 3.00±0.67,2.33±0.69,2.60±0.38kPa.Through statistical calculation,the average value of P is less than 0.01,which indicates obvious difference.In the improvement of respiration,except at 15 seconds the effect of calcium ion is more obvious than that of neostigmine,the other results have no statistical difference.Conclusion Neostigmine can effectively counteract poisoning caused bymagnesium ion,the counteractive effect is better more obvious than that of calcium ion.Through the experiment,a new effective method elieving poisoning caused by magnesium ion is provided. [