肝脏VX_2肿瘤声学造影的动态变化时相

Dynamic phases of hepatic VX 2 carcinoma in contrast second harmonic imaging

目的 观察兔肝脏VX2 肿瘤在二次谐波声学造影中的增强效果及动态变化时相。方法 1 7只接种VX2 肝肿瘤的新西兰白兔经外周静脉注射氟碳声学造影剂FX5 30 ,采用Sequoia5 1 2超声仪的二次谐波显像观察肿瘤造影增强过程 3min。结果 VX2 肿瘤在声学造影中出现了三个特异性的动态变化时相 ,即动脉相、门脉相和延迟相。动脉相 (造影后 5～ 1 0s)中出现肿瘤血管早期增强 ;门脉相 (造影后 1 0～ 30s)中肝实质逐渐增强 ,肿瘤血管影像减弱 ;延迟相 (造影 30s以后 )肝实质强烈增强 ,VX2 肿瘤呈弱回声病灶。结论 新型声学造影方法可以发现VX2 肿瘤特异性的造影动态变化 ,显著提高肿瘤诊断特异性。

Objective To assess the dynamic contrast enhancement of hepatic VX 2 tumor using second harmonic imaging. Methods A ultrasound contrast agent FX530 was administered to 17 VX 2 tumor bearing rabbits by the ear veins. Second harmonic imaging of Sequoia 512 was used to evaluate the contrast effects. Results Three dynamic phases appeared sequentially during the contrast process. Arterial phase occurred in the early 5～10 s period in which tumors feeding vessels were enhanced. Portal phase followed from 10～30 s showed that liver parenchyma was developed. In delayed phase, from 30 s to about 180 s, strong liver enhancement was achieved whereas VX 2 tumors became hypoechoic lesions. Conclusions The contrast ultrasonography can discover the characteristic dynamic phases of contrast enhancement of VX 2 tumor and significantly improve the specificity of diagnosing tumor.