子宫内膜浆液性乳头状腺癌30例临床病理分析

Clinical Pathological Analysis of 30 Cases of Uterine Papillary Serous Carcinoma

【目的】探讨子宫内膜浆液性乳头状腺癌（UPSC）的临床及病理特点。【方法】回顾性分析30例UPSC患者的临床资料，对其临床及病理特点做统计学分析。【结果】30例UPSC患者中，53．33％（16／30）的病例肌层浸润深度超过1／2肌层，60．00％（18／30）的病例有子宫外转移，淋巴转移率为43．33％（13／30），p53阳性率达到56．67％，雌激素受体（ER）和孕激素受体（PR）的阳性率分别为26．67％和30．30％。【结论】UPSC病期晚，易浸润深肌层和向子宫外扩散；p53的高表达及ER、PR的低表达预示患者预后不良。

[Objective] To explore the clinical and pathological characteristics of uterine papillary serous carcinoma. [Methods] Clinical data of 30 patients with uterine papillary serous carcinoma were analyzed retrospectively. The clinical and pathological features were analyzed by statistics. [Results] Among 30 patients with uterine papillary serous adenocar- cinoma, the patients with the depth of myometrial invasion more than a half of myometrium occupied 53.33 % （16/30）. Metastasis outside the uterus was found in 60.00% （18/30） of patients. The lymphatic metastasis rate was 43.33% （13/ 30）. The positive rate of p53 was 56. 670/00. The positive rate of ER and PR were 26.67% and 30. 30%, respectively. [Conclusion] The stage of uterine serous papillary carcinoma is late, and it is easy to infiltrate into deep myometrium and spread outside the uterus. The high expression of p53 and low expression of ER and PR indicates a poor prognosis.