常见可致药源性尿路结石的药物

Drugs Usually Causing Urinary Stone

本文通过检索国内外报道药源性肾结石的文献,对引起肾结石的药物进行分类归纳,总结可以引起肾结石的药物种类及发生机制,以帮助临床医师了解具有潜在引起肾结石风险的药物,规避药源性肾结石的发生率。引起肾结石的药物多由于长期大量用药所致,最常见的原型药物包括氨苯蝶啶、磺胺嘧啶、蛋白酶抑制剂等,药物代谢产物形成含钙或含嘌呤的结石。

To summarize the types of drugs that can cause urinary stones and its mechanisms inducing urinary stone,meanwhile help clinicians understand and avoid the risk of drug-induced renal stones,the literature on domestic and foreign reports of drug-induced renal stones were classified and summarized.Renal stones are often caused by the long-term and high-dose use of drugs.The most common prototype drugs include triamterene,sulfadiazine and protease inhibitors.Drug metabolites mainly form stones with calcium or purine.The understanding of the potential risk of renal stones caused by drugs can effectively prevent and reduce the incidence of drug induced renal stones.