雷帕霉素用于治疗神经退行性疾病研究进展

Research advances in Rapamycin against neurodegenerative disease

越来越多的研究表明,雷帕霉素作为一种传统的抗生素,表现出很强的抗老化作用,通过阻断哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR),影响了多种基本的细胞周期,细胞的生长和增殖,蛋白质合成和细胞自噬过程,从而为神经退行性疾病模型提供神经保护作用,包括帕金森病、阿尔茨海默病、亨廷顿病等。对近期关于雷帕霉素神经保护作用的研究成果予以综述。

In recent years,more and more studies indicate that Rapamycin（RAPA） as a traditional antibiotic that exerts strong anti-ageing effects in several species.By inhibiting the activity of mammalian target of Rapamycin（mTOR）,RAPA influences a variety of essential cellular processes,such as cell growth and proliferation,protein synthesis,and cell autophagy.Thus,it could provide neuroprotection in several experimental models for neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and so on.The molecular mechanisms underlying the neuroprotective effects of Rapamycin in recent studies were reviewed.