不同干燥工艺对制剂影响的研究进展

Effects of various drying technologies on preparations

干燥工艺在制剂工业上应用十分广泛。不同的干燥工艺对制剂产生的影响各不相同,它不仅会影响制剂的用药量、临床用药的安全性,还会间接影响到制剂的生产成本。通过介绍干燥及其工艺的基本理论,并结合各种干燥工艺的特点与适用性,对不同干燥工艺对药物制剂性质和质量的影响、干燥工艺在药物制剂各方面的应用现状和对干燥工艺优化或技术改进等方面的研究进展进行了综述,为各种干燥工艺的进一步研究、设计、优化和在制剂工业上的推广提供借鉴和帮助。

Drying technology is extensively used in preparation industry.Various drying processes have many kinds of effects on preparations.They will not only affect the dosage of preparation and the clinical safety of medication,but also indirectly affect the costs of production.In this paper,the basic theory of drying technology as well as the characteristics and applicability of all kinds of drying technology are introduced.The effects of various drying technologies on the characteristics and quality of preparation,the application status,and the technology optimization or improvements are also reviewed,so as to provide the reference and help for further research,design,and optimization of drying technology in preparation industry.