乌拉尔甘草化学成分研究

Chemical constituents from Glycyrrhiza uralensis

目的研究乌拉尔甘草Glycyrrhiza uralensis根的化学成分。方法利用硅胶、聚酰胺、MCI、ODS、Sephadex LH-20柱色谱,RP-HPLC等技术对乌拉尔甘草70%乙醇提取物的醋酸乙酯萃取部位进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定。结果分离得到14个化合物,分别鉴定为3,7-二甲基甘草黄酮醇(1)、甘草宁I(2)、甘草香豆酮(3)、8-甲雷杜辛(4)、2′-hydroxyisolupalbigenin(5)、异驴食草酚(6)、去氢粗毛甘草素D(7)、glycyrin(8)、甘草酚(9)、刺甘草查耳酮(10)、甘草查耳酮B(11)、isoangustoneA(12)、甘草宁G(13)、5,7,4′-三羟基-6,8-二异戊烯基异黄酮(14)。结论化合物1为新化合物,化合物2～7首次从该植物中分离得到。

Objective To study the chemical constituents from the roots of Glycyrrhiza uralensis. Methods The chemical constituents in ethyl acetate fraction of 70% ethanol extract from the roots of G, uralensis were isolated and purified by chromatography on silica gel, polyamide, MCI, ODS, Sephadex LH-20 columns, and RP-HPLC. The structures were identified on the basis of physicochemical properties and spectral data analyses. Results Fourteen compounds were isolated and identified as 3, 7-dimethyl licoflavonol （1）, gancaonin I （2）, licocoumarone （3）, 8-methylretusin （4）, 2＇-hydroxyisolupalbigenin （5）, isovestitol （6）, dehydroglyasperin D （7）, glycyrin （8）, glycyrol （9）, echinatin （10）, licochalcone B （11）, isoangustone A （12）, gancaonin G （13）, and 5, 7, 4＇-trihydroxy-6, 8-diisoprenylisoflavone （14）. Conclusion Compound 1 is a new compound, and compounds 2--7 are isolated from this olant for the first time.