摘要
目的观察过氧化酶体激活物增殖受体y(PPAR-y)在胃癌组织及胃腺癌细胞系(SGC7901)中的表达,并探讨其临床意义。方法采用免疫组化SP法,检测50例胃癌、癌旁组织以及SGC7901中PPAR-y的表达。结果PPAR-y蛋白在胃癌中的表达为58%,明显高于癌旁组织的表达(28%)(P〈0.01)。PPAR-y蛋白在SGC7901细胞系中呈阳性表达。PPAR-y蛋白在低分化癌组织、侵及浆膜层、有淋巴结转移(P〈0.01)和分期晚(P〈0.05)的胃癌组织中表达增高,与性别、年龄、肿瘤大小及肿瘤部位无关(P〉0.05)。结论PPAR-y蛋白在胃癌组织表达上调,提示PPAR-y蛋白不仅与胃癌的发生有关,而且与其进展有关,有可能作为检测胃癌的分子标志物并可提示其预后。
Objective To investigate the expression and significance of peroxisome proliferator - activated receptor y( PPAR - y) in gastric cancer patients and gastric cell line SGC7901. Methods SP immunohistochemistry was used to investigate PPAR - y expression in 50 cases of gastric cancer, their adjacent tissues and the SGC7901. Results The positive rate of PPAR - y protein expression was significantly higher in gastric cancer (58%)than that in their adjacent mucosa(28% )(P 〈0.01). The expression of PPAR-y was positive in SGC7901, and it was significantly high in poor differentiation, infiltration of serosa, lymph node metastasis ( P 〈 0. 01 ) and advanced tumor stage ( P 〈 0.05 ). It was irrelevant with gender, age, tumour size and location ( P 〉 0. 05 ). Conclusion Expression of PPAR-y protein is up - regulated in gastric cancer. PPAR - y is not only relevant with gastric cancer happening and its progression. There may be a molecular marker and prognostic factor of gastrie cancer
出处
《实用肿瘤学杂志》
CAS
2012年第5期394-398,共5页
Practical Oncology Journal
基金
基金项目:黑龙江省教育厅课题(11511166)