AEG-1和Caspase-3在三阴基底样乳腺癌中的表达及其临床病理相关性的研究

Expression of AEG - 1 and Caspase - 3 in triple negative basal - like breast cancer and their clinicopathological relationship

目的着重探讨AEG-1和Caspase-3在三阴基底样癌组织中的表达及其相关性。方法HE染色对66例检测对象的病理学诊断进行验证；免疫组化检测66例三阴基底样癌中AEG-1和Caspase-3的表达，分析其与临床病理参数的关系及二者的相关性。结果66例检测对象均为三阴基底样癌；AEG-1和Caspase-3蛋白在三阴基底样癌组织中的阳性表达率分别为73％和60％；AEG-1在三阴基底样癌中的表达随着肿瘤分化程度的降低而增强，在血清学CA153阳性中的表达率显著高于阴性中的表达率，表达差异具有统计学意义（P〈0．05）；Caspase-3在三阴基底样癌中的表达随着肿瘤分化程度的降低而减弱，在血清学CA153阳性中的表达率显著低于阴性中的表达率，表达差异具有统计学意义（P〈0．05）；AEG-1和Caspase-3在三阴基底样癌组织中表达无相关性。结论AEG-1和Caspase-3参与三阴基底样癌的发生和发展。但是AEG-1不能单独直接抑制Caspase-3的表达，可能与CA153相互作用，共同抑制Caspase-3的表达。

Objective To prove AEG - 1 and Caspase - 3 expressions of basal - like cancer tissues and their relevance. Methods HE staining was used to verify the pathological diagnosis of cases. Immunohistochemistry was used to detect the expression of AEG - 1 and Caspase - 3 in 66 basal - like cancer. Results 66 eases were all basal - like cancer,respectively. The positive expression rates of AEG - 1 and Caspase - 3 were 73% and 60% in basal - like cancer, respectively. The expression of AEG - 1 in basal - like cancer tissues increased with the reduction of the differentiation level, and signi^cantly higher in basal -like cancer with CA153 high than that in basal - like cancer without CA153 high, （P 〈 0.05 ）. The expression of Caspase - 3 in basal - like cancer tissues decreased with the reduction of the differentiation level, and was significantly lower in basal - like cancer with CA153 high than that in basal - like cancer without CA153 high （ P 〈 0.05 ）. AEG - 1 and Caspase - 3 expressions in basal - like breast cancer tissues were negatively correlated, however it was not statistically significant （ P 〉 0.05 ）. Conclusion AEG - 1 and Caspase - 3 maybe participate in progression of basal - like cancer. But, AEG - 1 does not directly inhibit the expression of Caspase -3. It maybe interact with the CA153, as a cofactor in inhibiting the expression of Caspase -3.