我国北方汉族女性乳腺癌中PELP1／MNAR表达特征及其与Ki-67标记指数相关性研究

Features of PELP1/MNAR expression in tumor from north of China resident Han ethnic female primary breast cancer patients and its correlation with Ki -67

目的观察我国北方汉族女性乳腺癌患者肿瘤组织中PELP1／MNAR表达特征及其与临床病理参数及Ki-67表达的相关性。方法采用免疫组化法检测98例北方汉族女性乳腺癌患者及22例乳腺良性纤维腺瘤患者肿瘤组织中PELP1／MNAR、Ki-67表达水平，比较PELP1／MNAR在乳腺良恶性肿瘤中的表达差别，就乳腺癌组织中PELP1／MNAR表达水平与临床参数及Ki-67表达水平进行相关性分析。结果乳腺癌组织中PELP1／MNAR表达阳性率显著高于良性乳腺纤维腺瘤组织（100％VS72．7％，P〈0．01）；乳腺癌组织中PELP1／MNAR表达强度与患者年龄、是否绝经、肿瘤病理分型未见相关性（P〉0．05），与临床等级呈显著正相关（r=0．442，P〈0．01）；有淋巴结转移组PELP1／MNAR表达强度显著高于无淋巴结转移组（56．35V843．19，P=0．015）；PELP1／MNAR与Ki-67表达水平呈显著正相关（r=0．247，P=0．014）。结论PELP1／MNAR高表达是我国北方汉族女性原发性乳腺癌的一个特征并且可能成为判断乳腺癌预后的一个重要病理学指标。

Objective To investigate the correlation of expression of proline - ,glutamic acid - ,leucine -rich protein- 1/modulator of nongenomic activity of estrogen receptor（PELP1/MNAR） with clinical index and Ki67 label index（ Ki -67 LI）in tumor from North of China resident Han ethnic female breast cancer patients. Methods 98 cases of primary breast cancer and 22 cases of benign breast fibroadenoma tissues from North of China resident Han ethnic patients were collected. Expression levels of PELP1/MNAR both in breast cancer and fibroadenoma specimens as well as Ki -67 only in breast cancer specimens were detected by immunohistochemistry （IHC）. Correlation analysis was performed to examine association between PELP1/MNAR expression and other clinical parameters as well as Ki -67 in breast cancer. Results The positive ratio of PELP1/MNAR in breast cancer was significantly higher than that in fibroadenoma （ 100% vs 72.7%, P 〈 0. 001 ）. The expression of PELP1/MNAR in breast cancer did not show significant correlation with age or pathological types, but appeared significantly positive correlation with clinical stage and lymph node metastatic state. A significant positive correlation between expression of PELP1/MNAR and Ki - 67 LI in breast cancer was also found （ r = 0. 247, P = 0.014）. Conclusion Higher expression of PELP1/MNAR in tumor is a character of North of China resident Han ethnic female primary breast cancer patients. PELP1/MNAR status may be served as a valuable pathological index in evaluating prognosis of primary breast cancer.