自拟疏肝解郁汤联合氟西汀治疗45例中风后抑郁的疗效分析

Efficacy analysis of treating 45 cases of post-stroke depression with the Shugan Jieyu decoction plus fluoxetine

目的:对自拟疏肝解郁汤联合氟西汀治疗中风后抑郁的临床疗效进行分析。方法:随机将91例中风后抑郁患者分为对照组和治疗组,对照组给予晨服氟西汀20mg/次,1次/d;在对照组基础上,治疗组加服自拟疏肝解郁汤。动态对比两组患者治疗前、治疗4周末和治疗8周末的HAMD评分和ADL评分,8周末临床疗效和治疗期间不良反应情况等。结果:治疗组治疗4周末和治疗8周末HAMD评分和ADL评分明显优于对照组,P<0.01;总有效率95.56%明显高于对照组76.09%,P<0.01;不良反应发生率2.22%,低于对照组17.39%,P<0.05。结论:自拟疏肝解郁汤联合氟西汀能够明显改善中风后抑郁患者的抑郁症状,提高日常生活活动能力,药物不良反应少,值得临床继续研究和推广。

Objective： To analyze the clinical efficacy of treating post-stroke depression with the Shugan Jieyu decoction plus fluoxetine. Methods： 91 patients with post-stroke depression were randomly divided into control group and treatment group, the control group given morning suit fluoxetine 20 rag/time, a/d; Based on in the control group, treatment group was given the Shugan Jieyu decoction for treatment. Dynamic contrast two groups of patients before treatment, treatment 4 weekend and treatment of 8 week end HAMD scores and ADL scores, 8 weekend clinical curative effect and adverse reactions during treatment situation arid so on. Results： The treatment group after 4 weeks of treatment and therapy of 8 weeks HAMD score and ADL score was significantly better than the control group （P〈0.01）; Total efficiency of 95.56% was significantly higher than 76.09% in control group, P〈0.01; 2.22% low incidence of adverse reactionsin was lower than 17.39% in the control group, P〈0.05. Conclusion： The Shugan Jieyu decoction plus fluoxetine significantly improved depressive symptoms in patients with post-stroke depression, improve activities of daily living, adverse medicine reactions, and worthy of continued research and extension.