小檗碱对改善大鼠动脉粥样硬化的影响及作用机制

The effects and mechanism of action on Berberine to Atherosclerosis in rats

目的:研究小檗碱对大鼠动脉粥样硬化的影响,并阐明其机制。方法:将30只大鼠随机分为5组,只饲基础饲料组作空白对照组(A),模型组(B)不予给药,C、D、E组给予不同剂量小檗碱,测定大鼠血液中TC、TG、LDL-C和HDL-C浓度,以及SOD活性和MDA水平。结果:给药大鼠与模型组相比较,TC、TG、LDL-C浓度明显降低(P<0.05),HDL-C浓度升高(P<0.05),SOD活性增强,MDA水平降低(P<0.05),SOD与MDA呈负相关。结论:小檗碱具有改善大鼠动脉粥样硬化的功效,可作为降血脂药应用于临床。

Objective： To study the effects on Berberine to Atherosclerosis in rats, and illustrate the mechanism of action. Methods ：The 30 rats were divided them into five groups randonfly,the control group was gived basic feed only, the model group wasn＇t gived dntgs,C,D,E group were gived different dose of Berberine,determined the concentration of TC,TG,LDL-C and HDL-C in rats blood. Determined the activity of SOD and level of MDA. Results：The treatment groups were compared with model group,The concentration of TC,TG,LDL-C were declined obviously（P〈0.05）.The concentration of HDL-C was inereased（P〈0.05）,file activity of SOD was strengthen,the level of MDA was declined （P〈0.05）,SOD and MDA were negative cobb＇elation . Concluslons：The Berberine can improve the symptom of atheroselerosis in rats, and can be used as a Lowering blood IApids drug in clinic.