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舒芬太尼和芬太尼对麻醉诱导和苏醒时血流动力学的影响

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摘要 目的:对比观察舒芬太尼和芬太尼在麻醉诱导和苏醒期间对血流动力学的影响。方法:将60例ASAI~Ⅱ级择期行上腹部手术的患者随机分成3组,每组20例。所有患者进行常规全麻操作,3组分别给予不同药物:A组给予舒芬太尼0.3μg/kg,B组给予舒芬太尼0.5μg/kg,C组给予芬太尼6.0μg/kg。所有患者连续监测收缩压(SBP)、舒张压(DBP)、心率(HR)、氧饱和度(SPO2)、心电图(ECG)、呼气末二氧化碳分压(PetCO2)和大脑双频指数(BIS)。结果:三组麻醉诱导后SBP、DBP、HR均较诱导前有显著性下降(P<0.05)。A、C组插入气管导管时,血流动力学变化均较B组有明显增高(P<0.05)。A、B两组在麻醉苏醒期呼吸恢复时间、呼唤睁眼时间、拔除气管插管的时间比C组显著缩短。结论:0.5μg/kg的舒芬太尼可明显抑制气管内插管引起的应激反应,维持血流动力学稳定性较好,在麻醉苏醒期,有利于术后呼吸管理,安全性更高。
作者 郝伟
出处 《北方药学》 2012年第11期48-49,共2页 Journal of North Pharmacy
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