吲哚布芬应用于PCI术后预防冠状动脉再狭窄的研究

To explore the prevention effect of indobufen on PCI patients with coronary artery restenosis

目的研究吲哚布芬对经皮冠状动脉介入治疗(PCI)术后患者的冠状动脉再狭窄的预防疗效。方法对入选的64例PCI术后患者随机分为观察组(n=32)和对照组(n=32),观察组给予吲哚布芬和氯吡格雷,对照组给予阿司匹林和氯吡格雷,进行为期6个月的观察。6个月后行冠脉造影,对两组患者的再狭窄率进行比较,对两组间的临床安全性进行比较。结果观察组和对照组PCI术后6个月的冠脉再狭窄率相当,差异无统计学意义(P>0.05),两组间临床安全性比较,观察组的安全性优于对照组。结论吲哚布芬与氯吡格雷联合使用预防冠状动脉再狭窄与阿司匹林联用氯吡格雷疗效相当,具有更好的临床应用安全性。

Objective To explore the prevention effect of indobufen on PCI patients with coronary artery restenosis.Methods 64 patients with PCI were selected and randomly divided into the experiment group（n=32） and control group（n=32）.The patients in experiment group were given anti-platelet indobufen and clopidogrel,in control group were given aspirin and clopidogrel for 6 months.After 6 months,coronary angiography were done,two groups of patients with restenosis rates were compared between the two groups,to compare the clinical safety.Results After 6 months,coronary restenosis rate（P 0.05） were similar in the experiment group and the control group,between the two groups clinical safety,the safety of experiment group was better than the control group.Conclusion The prevention effect of coronary artery restenosis were similar in patients between Indobufen、Clopidogrel and Aspirin、Clopidogrel,but the Indobufen and Clopidogrel was more safe.