奥拉西坦治疗脑梗塞恢复期患者轻度认知功能障碍的临床观察

Observation on treatment of mild cognitive impairment in patients with convalescent cerebral infarction with oxiracetam

目的探讨奥拉西坦治疗脑梗塞恢复期患者轻度认知功能障碍(MCI)的疗效。方法采用蒙特利尔认知评估量表(MoCA)作为认知功能的测评工具,将40例脑梗塞恢复期MCI患者随机分为治疗组与对照组各20例。治疗组应用奥拉西坦注射液,对照组用胞二磷胆碱,疗程均为21 d。比较两组的临床疗效及MoCA评分改善情况。结果治疗组MoCA评分明显升高,与治疗前比较差异有统计学意义(P<0.05);与对照组比较差异也有统计学意义(P<0.05)。结论奥拉西坦能改善脑梗塞恢复期患者的MCI。

Objective To investigate the effects of oxiracetam in the treatment of mild cognitive impairment（MCI） in patients with convalescent cerebral infarction.Methods Forty cases of MCI in patients with convalescent cerebral infarction were randomly divided into two groups with the montreal cognitive assessment scale（MoCA）.Treatment group,20 patients were treated with oxiracetam,the control group,20 patients were treated with citicoline,the course of treatment was 21d.Observing the clinical effect and the level of MoCA of two groups.Results After therapy,the level of MoCA of treatment group was improved siginificantly（P0.05）;And the level of MoCA of treatment group was higher than that of contral group,the difference was siginificant（P0.05）.Conclusion Treatment of oxiracetam is effective to improve cognitive function of convalescent cerebral infarction patients.