脓毒性休克液体复苏和容量治疗研究进展

Fluid resuscitation and volume therapy for septic shock

重症脓毒症常并发脓毒性休克。重症感染时，因严重的炎症反应，导致毛细血管渗漏、第三间隙液体积聚、血液异常分布、有效血容量减少，出现休克的临床表现。早期合理的液体复苏是降低脓毒性休克病死率的重要措施。液体复苏时机掌握、容量控制、疗效评估至关重要。

Septic shock is the most common complication in severe septic patients. These patients clinically present shock manifestations due to capillary leak, extravasation in the third space, the anomaly distribution of blood volume, and decreased effective circulating volume, secondary to the severe inflammatory reaction. Early reasonable fluid resuscitation is one of the main therapy to deduce the mortality of septic shock. The time point of fluid resuscitation, volume control, and therapeutic evaluation play important role in the treatment of septic shock.