血清胱抑素C联合β_2微球蛋白检测诊断儿童过敏性紫癜早期肾功能损伤的临床价值研究

The value of combined detection of cystatin C andβ_2-microglobulin in predicting early renal damage of children with Henoch-Schnlein purpura

目的探讨血清胱抑素C(Cys-C)和β_2微球蛋白(β_2-MG)联合检测对过敏性紫癜(HSP)早期肾损伤诊断的临床价值。方法选择明确诊断为HSP患儿45例,采用颗粒增强透射免疫比浊法测定血清Cys-C,放射免疫法测定血β_2-MG,并与健康对照组进行比较。结果 HSP患儿Cys-C、β_2-MG水平均显著高于健康对照组(P<0.01),联合检测的阳性率明显高于单项检测(P<0.01)。结论血清Cys-C和β_2-MG可作为HSP早期肾损伤的检测指标,联合检测能提高阳性率。

Objective To study the value of combined detection of cystatin C and β2-microglobulin （ β2- MG） in predicting early renal damage of children with Henoch-Schoenlein purpura（HSP）. Methods Forty-five children with HSP were selected. The particle enhanced transmission turbidimetric immunoassay was used for detecting serum cystatin （Cys C） and radio y for serum β2-MG. The results were compared with those of healthy control group. Results The levels of serum Cys C and β2-MG in children with HSP were higher than those of healthy control group（P 〈 0. 01 ）. The positive rate of combined detection was obviously higher than that of single detection （P 〈 0.01 ）. Conclusion Serum Cys-C and β2-MG can be used as the detection indexes of early renal damage, and combined detection can improve the positive rate.