扁桃酸及其衍生物对映体的手性识别研究

Studies on Chiral Recognition of Mandelic Acid and Its Derivatives Enantiomers

以两种手性氨基醇作为主体,运用1H NMR分别考察其对客体7个扁桃酸衍生物对映异构体的手性识别能力。结果表明,主客体物质的量之比为1∶1时,主体诱导客体对叔丁基扁桃酸消旋体最高产生37.6 Hz的化学位移差值。

The chiral recognition ability of these two chiral amino alcohols were evaluated as chiral solvating agent （host） for 7 mandelic acid derivatives enantiomers （guest） in the presence of an equimolar amount, respectively. As a result, the biggest chemical shift non-equivalences （△△δ） of 4-tert-butyl mandelic acid enantiomers induced by the two polydentate ligands was 37.6 Hz.