摘要
目的研究YB-1在宫颈癌中的高表达与宫颈癌病人预后的关系。方法用免疫组化方法,分析2002年1月～2009年1月经病理证实的46例宫颈癌标本组织中YB-1的表达,探讨YB-1与宫颈癌的关系,并用SPSS软件对结果进行分析。结果 YB-1高表达的宫颈癌患者复发率更高,并且有更短的无病进展期(P=0.035)和总的生存时间(P=0.013),多因素回归分析显示YB-1高表达是宫颈癌的独立预后因素。结论本项研究中,YB-1高表达患者预后差,YB-1高表达可能是宫颈癌独立预后因素。
Objective This study aimed at researching the effect of Y-box-binding protein-1（YB-1） in cervical cancer tissue,and the relationship between YB-1 and cervical cancer.Methods We selected 46 cervical cancer＇s tissues to detect YB-1 expression with immunity histochemical method.All of them were verified by pathology.Results Higher expression of YB-1 was associated with an increased potential for relapse,poor disease-free survival,and reduced overall survival.Higher expression of YB-1 could be an independent risk factor for poor prognosis in patients with cervical cancer.Conclusion Our data show that cervical cancer patients with higher expression of YB-1 have poor prognosis and YB-1 may be independent prognostic factors of cervical cancer.
出处
《西部医学》
2012年第10期1876-1878,1884,共4页
Medical Journal of West China
基金
四川省卫生厅基金课题(No:110543)
关键词
YB-1
宫颈癌
预后
Y-box-binding protein-1
Cervical cancer
Prognosis
