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心肌缺血后适应的保护作用及机制研究进展 被引量：7

Study progress on protective effects and mechanisms of myocardial ischemic postconditioning
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摘要 急性心肌梗死发病率的增高,促进了再灌注治疗如溶栓及经皮冠脉介入治疗的应用.这却引起了心肌细胞死亡、血流动力学障碍、再灌注心律失常及内皮功能障碍等缺血再灌注损伤[1].众多研究证实,缺血后适应对缺血再灌注损伤心肌具有保护作用,能够降低梗死面积[2]、减少细胞凋亡[3]、改善内皮功能[4]及减轻组织的水肿[4]等.缺血后适应,即在心肌缺血再灌注的即刻对冠脉进行短暂、重复的开通及再闭过程,随后恢复冠状动脉血流[4].后适应的可操作性,决定了其在临床中应用的可能性.本文就后适应在心肌缺血再灌注损伤中的保护应用及其机制进行综述.
作者 张苗苗 于海奕
机构地区 煤炭总医院心脏中心 北京大学第三医院心内科
出处 《中国心血管病研究》 CAS 2012年第9期704-707,共4页 Chinese Journal of Cardiovascular Research
关键词 心肌梗塞 缺血再灌注 缺血后适应 再灌注损伤 Myocardial infarction Ischemia-reperfusion Ischemic postconditioning Reperfusion injury
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献26

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二级参考文献21

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共引文献17

同被引文献72

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引证文献7

二级引证文献15

中国心血管病研究
2012年 第9期

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