摘要
目的探讨99m锝-甲氧基异丁基异腈(99Tcm-MIBI)双时相显像在原发性甲状旁腺功能亢进症(PHPT)定位诊断中的应用价值。方法选取11例健康体检者(正常对照组)和35例经手术和病理证实为PHPT的患者(PHPT组),均行99Tcm-MIBI双时相显像,同时采用计算机感兴趣区(ROI)技术计算甲状旁腺组织ROI中平均放射性计数与相邻正常甲状腺组织ROI的摄取比值(T/NT)。同期35例PHPT患者进行B超检查,23例进行CT检查。所有显像结果均与临床手术病理结果进行比较,计算灵敏度;比较正常对照组与PHPT组的99Tcm-MIBI T/NT值。结果 (1)35例PHPT患者,99Tcm-MIBI双时相显像诊断PHPT的灵敏度为91.4%(32/35);同期B超诊断的灵敏度为62.8%(22/35);CT诊断的灵敏度为73.9%(17/23)。99Tcm-MIBI双时相显像诊断PHPT的灵敏度显著高于B超及CT检查,差异有统计学意义(P<0.05),且B超诊断PHPT的灵敏度与CT检查比较,差异亦有统计学意义(P<0.05)。(2)PHPT组早期相及延迟相99Tcm-MIBI T/NT值均显著高于正常对照组,差异有统计学意义(P<0.01)。结论 99Tcm-MIBI双时相显像能较准确地诊断PHPT,具有较高的临床应用价值。
Objective To evaluate the clinical value of double phase ^99mTc^m-MIBI imaging in the localization diagnosis of primary hyperparathyroidism (PHPT) . Methods Double phase ^99mTc^m-MIBI imaging was performed in 11 normal controls and 35 PHPT patients proved by surgery and pathology. Region of interest (ROI) technology was used to calculate average radio- active count of parathyroid tissues and T/NT of adjacent normal tissues. Meanwhile, 35 PHPT patients were given B ultrasound test and 23 eases were given CT test. All the imaging results were compared with surgery and pathology results to calculate sensitivity. The ^99mTc^m- MIBI T/NT values of the control group and PHPT group were compared. Results ( 1 ) In the 35 PHPT patients proved by surgery and pathology, the sensitivity of double - phase 99Tern - MIBI imaging in the diagnosis of PHPT was 91.4% ( 32/35), while the sensitivity of B ultrasound and CT was 62. 8% (22/35) and 73.9% (17/23) respectively. The sensitivity of double -phase 99Tcm -MIBI imaging was significantly higher than that of ultrasound and CT (P 〈 0. 05 ) , and the difference of sensitivity between ultrasound and CT was also statistically significant (P 〈 0. 05 ) . (2) The ^99mTc^m-MIBI T/NT values of early phase and delayed phase in the PHPT group were both significantly higher than those of the control group (P 〈0. 01 ). Conclusion Double phase ^99mTc^m- MIBI imaging can accurately diagnose primary hyperparathyroidism and has high clinical value.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第30期3559-3560,3564,共3页
Chinese General Practice