经鼻蝶窦切除垂体生长激素腺瘤疗效分析

The analysis of the effect of transsphenoidal microsurgical operation in patients with prolatinomas

目的评估垂体生长激素（GH）腺瘤的侵袭性及经鼻蝶窦显微外科手术对其近期疗效的影响。方法收集并分析22例GH腺瘤患者的临床资料，分别检测术前和术后第3天、术后1个月血清GH平，按照Wilson改良Hardy分类方法判断肿瘤侵袭性。所有患者均由同一手术者进行经鼻蝶窦显微外科手术治疗，分析侵袭性与非侵袭性腺瘤的临床疗效。结果22例GH腺瘤患者，侵袭性腺瘤11例，非侵袭性腺瘤11例。侵袭性与非侵袭性GH腺瘤患者术后好转率差异无统计学意义（P〉0．05）。GH≤50μg／L患者与〉50μg／L患者术后治愈缓解率差异无统计学意义（P〉0．05）。结论GH腺瘤侵袭性与近期手术疗效可能无差异。

Objective To assess the recent effect of the invasiveness and transsphenoidal mierosurgical oper- ation in the treatment of growth hormone-secreting adenom tumor. Methods The data of 22 patients with growth hor- mone（GH） adenomas were collected. All patients were tested preoperative GH level and that within the first 3 days, 30 days following surgery. The invasiveness of pituitary adenomas was judged according to Hardy＇s classification scheme modified by Wilson. Results There were 22 patients with GH-secreting pituitary adenomas,8 males and 14 females, 11 patients with invasive adenomas and 11 patients with noninvasive adenomas. The remission rate between the patients with invasive adenomas and the patients with non-invasive adenomas had no statistically significant differ- ence（ P 〉 0. 05 ）. The postoperative remission rate of patients with GH values ≤ 50μg/L was no significantly lower than that of 〉 50μg/L（ P 〉 0. 05 ）. Conclusion The recent effects of operation were not significantly different with the invasiveness of tumor.