氟伐他汀对冠心病患者白细胞介素-6、基质金属蛋白酶-1和脂联素水平的影响

The influence of fluvastatin on the levels of IL-6, MMP-1 and APN in patients with coronary heart diseases

目的探讨氟伐他汀对冠心病患者白细胞介素-6（IL-6）、基质金属蛋白酶-1（MMP-1）和脂联素（APN）水平的影响。方法选择冠心病患者60例，随机平均分为氟伐他汀40mg治疗组和80mg治疗组；另外选择健康对照者20例。测定治疗前后IL-6、MMP-1和APN浓度。结果冠心病患者治疗前IL-6和MMP-1高于对照组（t=4．896、4．231，均P〈0．05），APN低于对照组（t=4．352，P〈0．05）；两组治疗后IL-6和MMP-1均有明显下降，APN明显升高（t=4．156、4．121、4．553，均P〈0．05），但80mg组更显著（t=3．786、3．690、4．110，均P〈0．05）。结论在冠心病患者中，血清IL-6、MMP-1水平明显升高，APN水平明显降低，可能与炎性反应有关；氟伐他汀可能通过降低IL-6、MMP-1的水平，升高APN水平而发挥抗炎作用，并与药物浓度相关。

Objective To explore the influence of fluvastatin on the levels of IL-6, MMP-1 and APN in pa- tients with coronary heart diseases. Methods 60 patients with coronary heart diseases were randomly divided into 2 groups ：40mg group and 80rag group treated by fluvastatin and 30 healthy persons were selected as control group, ser- um levels of IL-6, MMP-1 and APN were measured before and after treatmead. Results Serum levels of IL-6, MMP- 1 were significantly increasd in the coronary heart diseases group（ t = 4. 896,4. 231, all P 〈 0.05 ）. Serum level of APN was significantly decreasd in the coronary heart diseases group（ t = 4. 352, P 〈 0.05 ）. The serum levels of IL-6 and MMP-1 were significantly decreasd after therapy （4. 156,4. 121,4. 553, all P 〈 0. 05 ）. The decrease of serum lev- els of IL-6 ,MMP-1 in 80mg group was more significant than those of 40mg group（ t = 3. 786,3. 690,4.10, all P 〈 0. 05）. Conclusion Serum concentrations of IL-6 and MMP-1 increase, but APN decrease in patients with coronary heart diseases. Serum concentrations of IL-6, MMP-1 and APN had relationships with coronary plaque extent. Fluvasta- tin could decrease serum levels of IL-6 and MMP-1 ,increase serum level of APN in patients with coronary heart disea- ses, and have a beneficial effect on steadying the plaque.