川崎病160例临床分析

Chinical analysis of 160 cases of Kawasaki disease

目的：探讨川崎病（KD）的临床特征、实验室检查、冠脉损害的危险因素及治疗方法。方法：我院儿科2000年1月~2010年1月诊治的160例KD患儿资料进行了回顾性分析和总结。结果：160例KD中典型126例,不典型34例,男112例,女48例。年龄最小6个月,最大11岁。〈1岁41例,1~3岁68例,3~5岁21例,〉5岁30例。平均发病年龄2岁6个月。合并冠脉损害者44例,其中冠脉扩张26例,冠脉瘤13例,巨大冠脉瘤5例。对合并冠脉损害者随访6个月至3年,完全恢复正常40例,5例巨大冠脉瘤患者,1例完全恢复,其余4例未恢复。结论：不典型KD冠脉损害率高,发病10 d内用丙球效果好,2g/kg单次注射,明显优于每日0.4 g/kg连用5 d的疗法,WBC升高,ALB降低,男性及发热时间长是KD合并冠脉损害的危险因素。

Objective：To investigate the clinical features,laboratory examination,risk factors of coronary artery lesions and treatment for kawasaki disease.Methods：A total of 160 patients with Kawasaki disease hospitalized in Inner Mongolia Forestry General hospital during Janualy 2000 and Janualy 2010 were reviewed.Results：Among 160cases,126 were diagnosed with typical KD and 34 atypical（incomplete） KD;112were male and 48 were female,male to female ratio is 2.2：1.the age was between 6 months and 11years old;21 between 3～5 years old,30 over 5 years old.The mean age was 2 years and 6 months old.Totaly 44 cases were complicated with coro-nary artery lesions,including 26 coronary artery dilations,13 coronary artery aneurysms and 5 giant coronary artery aneu-rysms.the patients with CA lesions were followed up from 6 months to 3 years,40cases regressed completely,1 of 5 cases with giant CA aneurysmreg ressed completely,and other 4 cases didn＇t regress,1 case complicated with coronary thrombo sis.Conclusion：Atypical KD has higher prevalence of CA lesions.Children receiving IVIG 2 g/kg in the early 10 d ays of KD has little chance of CAL.The sing ledose of 2g/kg IVIG administration has better outcome.Jhe risk factors of CA le-sions incoude high WBC count,low ALBlevel ,male children and persistent fever.