氟比洛芬酯联合舒芬太尼用于剖宫产手术后静脉镇痛的研究

Postoperative Analgesia with Flurbiprofen Axetil Combined with Sufentanil in Patients Underwent Cesarean Operation

目的:比较剖宫产手术后患者自控静脉镇痛(PCIA)中氟比洛芬酯联合舒芬太尼与单纯舒芬太尼的镇痛效果及不良反应。方法:选择剖宫产手术术后行PCIA患者58例,随机均分为两组。舒芬太尼组(A组)术后镇痛给予舒芬太尼250μg/250ml;氟舒芬组(B组)术后镇痛给予舒芬太尼125μg+氟比洛芬酯150 mg/250 ml。两组PCIA泵的设置维持量0.4 ml/h,单次负荷剂量1.6ml,锁定时间10 min。观察两组镇痛开始时及开始后2、4、8、24、48 h的疼痛评分、生命体征和不良反应发生率。结果:两组术后镇痛评分差异无统计学意义。B组药物不良反应发生率低于A组(P<0.05)。结论:氟比洛芬酯联合舒芬太尼用于剖宫产手术后PCIA的镇痛效果与单纯舒芬太尼组相似,但不良反应明显降低。

Objective：To access the analgesia effect and side effect of flurbiprofen axetilcombined with sufentanil.Methods： Fiftyty-eight patients underwent cesarean operation were randomlydivided into two groups with twenty-nine cases each.Group A was given sufentanil 250 ug diluted to 250 ml via PCIA after surgery.Group B was given Sufentanil 125 ug plus flurbiprofen axetil 150mg diluted to 250 ml via PClA after surgery.The PCIA pump was set at a rate of 0.4 ml/h,bolus dose was 1.6 ml Lockout time interval was 10 min.Analgesia grade was accessed.vital sign and side effects were recorded.Results： Fhere was no significant difference in analgesia grade between two groups.The side effects were lower in group B than those in group A.Conclusion： Flurbiprofen axetilcombined with sufentanil can obtain similar analgesia effects to sufentanil alone,but can reduce side effects and fever temperature.