摘要
近年来,血型物质(Blood GroupSubstance)已作为一种新的肿瘤标记应用于肿瘤研究。本文应用血型物质 A,B,H 三种单克隆抗体,对一组胃癌组织作免疫组化染色,观察三种抗原在胃癌组织中的消长情况,并对其在胃癌研究中的实际意义加以讨论.1 材料与方法本文收集资料完整的78例胃癌手术切除标本,福马林固定,石蜡包埋。所用的血型物质 A,B,H 单克隆抗体为美国 Dako 公司产品,组织染色 S-P 药盒为美国 Zyntd
The expression of blood group antigen A,B and H were demonstrated in the tissues of gastric car- cinoma with immunohistochemical method.The results indicated that the deletion of A,B and H anti- gen was found in 28 of 78(35.9%)patients with gastric carcinoma.The loss of antigen was higher in poorly diffentiated than well differentiated carcinoma (P<0.05).Incompatible A or B antigen expres- sion occurred in 8.8% of cases.These alterations is considered to be immunological dedifferentiation of tumor cell.It is concluded the blood group antigen would be regarded as an tumor marker in the study of gastric carcinoma.
