122对母婴风疹病毒抗体水平检测及意义

122 Maternal-infant pairs comparative study and discussion on the rubella antibody level

目的了解孕产妇及其新生儿血液中风疹病毒抗体水平,评估孕产妇及其新生儿对风疹病毒的易感性,为预防和控制先天性风疹综合征提供科学依据。方法随机采集2011年吉林大学第二医院妇产科住院部分孕产妇及其配对新生儿血液,应用酶联免疫吸附法(ELISA)检测血清中风疹病毒特异性抗体。运用统计学软件SPSS对可能影响孕产妇及其新生儿风疹抗体水平的因素进行分析。结果 122名孕产妇风疹抗体免疫球蛋白G(IgG)阳性率为77.8%,新生儿风疹抗体IgG阳性率为82.6%。一对母婴风疹IgG抗体均>2 500 IU/ml,其母亲的风疹抗体免疫球蛋白M(IgM)阳性。母体内风疹病毒IgG抗体阳性率随年龄增加而下降。母传抗体增高的平均倍数为1.5倍,降低的倍数为2.0倍。结论及时监测孕产妇及其新生儿风疹IgG及IgM抗体,提高育龄妇女风疹免疫力,是减少先天性风疹综合征发病的有效手段。

Objective To analyze the rubella antibody level of comparison in maternal-infant pairs,and provide scientific basis for controlling and preventing congenital rubella syndrome（CRS）.Methods Newborn and their mothers were collected as object from No.2 hospital attached Jilin University in 2011.Their serum samples were tested by the method of ELISA,and the data were analyzed for the rubella antibody level from some way by statistic software.Results The positive rate of rubella antibody IgG was 77.8% in mothers,the positive rate of rubella antibody IgG was 82.6% in infants.Rubella antibody IgM was positive in one mother and the maternal-infant rubella antibody IgG were more than 2500 IU/ml.With age increasing,the positive rate decreased.Maternal-transferred rubella antibody IgG increased 1.5-fold and also maternal-transferred rubella antibody IgG decreased 2.0-fold.Conclusion The effective way to reduce the congenital rubella syndrome is to test rubella antibody IgG and IgM on time in pregnant women and infants,and establish good vaccinate strategies for women at childbearing age.