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前列腺癌组织中原癌基因Aurora-A的表达变化 被引量：2

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摘要 目的对前列腺癌组织中原癌基因Aurora-A的表达变化情况进行分析探讨。方法随机抽取在2009年3月至2012年3月本院收治的前列腺癌患者42例和同期健康体检者45例作为研究对象,采用免疫组化法对其前列腺癌组织的Aurora-A蛋白进行检测,对两组研究对象的Aurora-A的表达情况进行对比分析。结果统计发现,癌症组患者的Aurora-A蛋白呈现阳性者34例(80.95%),Aurora-AmRNA的表达量为(1.16±0.48);健康组Aurora-A蛋白阳性率和Aurora-AmRNA的表达量均较癌症组低,且两组差异具有统计学意义(P<0.05)。结论前列腺癌患者的Aurora-A蛋白和Aurora-AmRNA均呈现出明显的高表达,对患者的Aurora-A蛋白和Aurora-AmRNA进行检测,对于诊断和病情评估等均具有重要意义。
作者 朱安峰
机构地区 吉林省长春市中心医院病理科
出处 《中国实用医药》 2012年第27期88-89,共2页 China Practical Medicine
关键词 前列腺癌 组织 AURORA-A AURORA-A MRNA 表达
分类号 R737.25 [医药卫生—肿瘤]
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共引文献9

同被引文献11

  • 1张健,石松生,刘楠,郑安,杨卫忠.STK15基因在神经胶质瘤中的表达[J].中国临床神经外科杂志,2006,11(9):538-540. 被引量：5
  • 2Wang XX,Na L,Bo N. Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells[J].Molecular Cancer Research,2012,(5):588-596.
  • 3Zhang H,Chen X,Jin Y. Overexpression of Aurora-A promotes laryngeal cancer progression by enhancing invasive ability and chromosomal instability[J].European Archives of Oto-Rhino-Laryngology,2012,(2):607-614.
  • 4Yusuke A,Eiichi OI,Takamitsu H. A single starfish Aurora kinase performs the combined functions of Aurora A and Aurora B in haman cells[J].Journal of Cell Science,2010,(22):3978-3988.
  • 5Dora S,Nicholas HB,Renata B. Drosophila Ajuba is not an Au rora-A activator but is required to maintain Aurora-A at the centrosome[J].Journal of Cell Science,2011,(7):1156-1166.
  • 6Angelo C,Tiziana G,Laura M. Expression patterns of Aurora A and B kinases,Ki-67 and the estrogen and progesterone receptors determined using an endometriosis tissue microarray model[J].Human Reproduction,2011,(10):2731-2741.
  • 7Chris PG,Guermarie VT,Ji Hyun S. Aurora B kinase phosphorylates and instigates degradation of p53.PNAS[J].2012,(24):E1513-E1522.
  • 8付达华,熊典虹,刘志礼,陈雅静,刘升.Aurora-B激酶在肺腺癌组织中的表达及其临床意义[J].南昌大学学报（医学版）,2010,50(2):31-34. 被引量：5
  • 9王新平,李国庆.Aurora-A和Aurora-B在人胃癌组织中的表达及意义[J].中国现代医药杂志,2010,12(12):26-28. 被引量：6
  • 10罗赟,刘志礼,舒勇,黄山虎,黄伟.Aurora-B在骨肉瘤中的表达及与远处转移的关系[J].中国现代医学杂志,2011,21(14):1611-1614. 被引量：3

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中国实用医药
2012年 第27期

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