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青藤碱对博莱霉素致小鼠肺纤维化的影响及其机制 被引量：5

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摘要 肺间质纤维化的发病率逐年增加，传统治疗效果欠佳且不良反应多。青藤碱具有抗炎、抗氧化及免疫抑制等作用，近年的研究结果显示，青藤碱还具有抗肾纤维化的作用。
作者 门翔 李蕴麟 曾晓丽 刘晓菊
机构地区 兰州大学第一医院老年呼吸科 兰州市中医医院风湿骨病科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2012年第10期783-785,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
关键词 青藤碱 肺纤维化 博莱霉素 小鼠 肺间质纤维化 抗肾纤维化 不良反应 治疗效果
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献6

  • 1程悦,郭东阳,张凡,王涛,张光明,郑宇,袁发焕.盐酸青藤碱对体外培养的系膜增生性肾炎患者外周血淋巴细胞相关因子表达的调节作用[J].中华肾脏病杂志,2010,26(6):474-475. 被引量：4
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二级参考文献17

  • 1杨汝春,王永钧,林京莲,周大为,朱晓玲.青藤碱对白介素1β诱导的肾小管上皮细胞骨架变化和明胶酶活性的影响[J].中华肾脏病杂志,2006,22(8):499-502. 被引量：8
  • 2徐红,毕增祺,周紫娟.青藤碱对腹膜透析患者超敏C反应蛋白的影响[J].中华肾脏病杂志,2006,22(12):747-748. 被引量：6
  • 3张德平,邱慧,庄谊,孟凡青.姜黄素干预对博莱霉素诱导的大鼠肺纤维化的影响[J].中华结核和呼吸杂志,2007,30(3):197-201. 被引量：10
  • 4张德平,庄谊,殷凯生.肌成纤维细胞凋亡与肺纤维化[J].国际呼吸杂志,2007,27(4):298-301. 被引量：7
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  • 10Zhong L, Wu CH, Lee WH, et al. Zeta-associated protein of 70 kDa ( ZAP 70), but not Syk, tyrosine kinase can mediate apoptosis of T ceils through the Fas /Fas ligand, caspase-8 and caspaseo3 pathways. J Immunol, 2004, 172: 1472-1482.

共引文献9

同被引文献46

  • 1孙文铸,毕黎琦.大鼠肺纤维化形成过程中IGF-Ⅰ和TGF-β_1的表达[J].吉林大学学报（医学版）,2007,33(2):231-233. 被引量：5
  • 2Bocehino M, Agnese S, Fagone E, et al. Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in idiopathiepulmonary fibrosis[J]. PLoS One, 2010,16 : e14003.
  • 3Daniil ZD,Papageorgiou E,Koutsokera A, et al. Serum levels of oxidative stress as a marker of disease severity in idiopathic pulmonary fibrosis[J]. Pulm Pharmacol Ther, 2008, 21 : 26- 31.
  • 4Hamdy MA, E1 Maraghy SA, Kortam MA. Modulatory effects of cureumin and green tea extract against experimentally induced pulmonary fibrosis: acomparison with N acetyl cysteine[J]. J Biochem Mol Toxicol, 2012,26: 461- 468.
  • 5Lee JC, Kinniry PA, Arguiri E, et al. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation induced pulmonary fibrosis,andimproves survival in mice[J]. Radiat Res, 2010,173 : 590 -601.
  • 6Xu M, Deng B, Chow YL, et al. Effects of curcumin in treatment of experimental pulmonary fibrosis: a comparison with hydrocortisone [J ]. J Ethnopharmacol, 2007,112 : 292- 299.
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引证文献5

二级引证文献12

中华结核和呼吸杂志
2012年 第10期

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