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Neuroprotective effects of the immunomodulatory drug Setarud on cerebral ischemia in male rats

Neuroprotective effects of the immunomodulatory drug Setarud on cerebral ischemia in male rats
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摘要 immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesized that Setarud will have a neuroprotective effect against ischemic cerebral injury. To validate this hypothesis, rats were intraperitoneally administered with 0.66 mL/kg Setarud for 30 minutes after middle cerebral artery occlusion. Triphenyltetrazolium chloride staining showed that Setarud could reduce cerebral infarct volume of rats subjected to cerebral ischemia. Transmission electron microscopy and hematoxylin-eosin staining results showed that Setarud could alleviate the degenerative changes in cortical neurons of rats with cerebral ischemia. The inclined plate test and prehensile test showed that Setarud could significantly improve the motor function of rats with cerebral ischemia. These findings suggest that Setarud shows neuroprotective effects against ischemic brain injury. immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesized that Setarud will have a neuroprotective effect against ischemic cerebral injury. To validate this hypothesis, rats were intraperitoneally administered with 0.66 mL/kg Setarud for 30 minutes after middle cerebral artery occlusion. Triphenyltetrazolium chloride staining showed that Setarud could reduce cerebral infarct volume of rats subjected to cerebral ischemia. Transmission electron microscopy and hematoxylin-eosin staining results showed that Setarud could alleviate the degenerative changes in cortical neurons of rats with cerebral ischemia. The inclined plate test and prehensile test showed that Setarud could significantly improve the motor function of rats with cerebral ischemia. These findings suggest that Setarud shows neuroprotective effects against ischemic brain injury.
作者 Farzaneh Vafaee Nasser Zangiabadi Fatemeh Mehdi Pour Farzaneh Dehghanian Majid Asadi-Shekaari Hossein Karimi Afshar
机构地区 Neuroscience Research Center Neuroscience Research Center Member of Research Committee
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第27期2085-2091,共7页 中国神经再生研究（英文版）
基金 supported by a grant from the Vice Chancellor of Research at Kerman Medical University
关键词 immunomodulatory drug stroke prehensile test antioxidant inclined plate test cerebral infarct CORTEX NEUROPROTECTION brain injury neural regeneration immunomodulatory drug stroke prehensile test antioxidant inclined plate test cerebral infarct cortex neuroprotection brain injury neural regeneration
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献30

  • 1Khairandish P, Mohraz M, Farzamfar B, et al. Preclinical and phase 1 clinical safety of Setarud (IMOD^TM), a novel immunomodulator. DARU. 2009;17(3):148-156.
  • 2Khorram-Khorshid HR, Abdollahi M, Novitsky YA, et al. Studies on potential mutagenic and genotoxic activity of Setarud. DARU. 2008;16(4):223-228.
  • 3Baghaei A, Esmaily H, Bdolghaffari AH, et al. Efficacy of Setarud (IMOD), a novel drug with potent anti-toxic stress potential in rat inflammatory bowel disease and comparison with dexamethasone and infliximab. Indian J Biochem Biophys. 2010;47:219-226.
  • 4Khorram-Khorshid HR, Azonov JA, Novitsky YA, eta Hepatoprotective effects of setarud against carbon tetrachloride-induced liver injury in rats. Indian J Gastroenterol. 2008:27:110-112.
  • 5Khorram-Khorshid HR, Azonov JA, Novitsky YA, et al. Protective effects of setarud (IMODTM) on development of diet-induced hypercholesterolemia in rabbits. DARU. 2008;16(4):218-222.
  • 6Gemma C, Mesches MH, Sepesi B, et al. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar-adrenergic function and increases in proinflammatory cytokines. J Neurosci. 2002;22: 6114-6120.
  • 7Caplan LR. Treatment of acute stroke: still struggling. JAMA. 2004;292:1883-1885.
  • 8Durukan A, Tatlisumak T. Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behave. 2007;87:179-197.
  • 9Sweeney MI, Kalt W, MacKinnon SL, et al. Feeding rats diets enriched in Iowbush bluberries for six weeks decreases ischemia-induced brain damage. Nutr Neurosci 2002:5:427-431.
  • 10Panahi M, Asadi-Shekaari M, Kalantaripour TP, et al. Aqueous extract of date fruit protects CA1 neurons against oxidative injury: an ultrastructural Study. Curr Topics Nutraceutical Res. 2008;6(3):125-130.
Neural Regeneration Research
2012年 第27期

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