白念珠菌致病相关的水解酶

Pathogenic hydrolases of Candida albicans

白念珠菌是一种重要的人类致病性真菌,其致病机制与多种因素有关。水解酶是白念珠菌最重要的毒力因子之一,在其入侵宿主过程中起关键作用。白念珠菌水解酶包括分泌型天冬氨酸蛋白酶、磷脂酶和脂肪酶,介导白念珠菌的表型转换、对宿主组织的黏附及对宿主免疫系统的干预,使其能够入侵宿主组织和逃避宿主的免疫防御机制。该文我们综述了白念珠菌水解酶的生物学属性和致病机制的研究进展。

Candida albicans is an important pathogenic fungus for human. Its pathogenicity is associated with various factors. Hydrolases belong to one of the most important virulence factors of C. albicans , which play a key role in fugal invasion. Pathogenic hydrolases of C. albicans comprise secreted aspartyl proteinases, phospholipases and lipases, which mediate phenotype conversion, adhesion to host tissue and intervention with host immune system. With these hydrolases, C. albicans is facilitated to invade host tis- sue and escaped from host anti-fungal immunity. Here we reviewed the updated studies in the biological and pathogenicity of C. albicans virulent hydrolases.